Type

Journal Article

Authors

Finian Martin
Catherine Godson
Denise Sadlier
Caitríona McEvoy
Eoin Brennan

Subjects

Medicine & Nursing

Topics
patients architecture kidney failure chronic genome wide association studies type 1 chronic kidney disease genetics diabetic nephropathy

The genetics of diabetic nephropathy. (2013)

Abstract Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy (DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a heritable genetic susceptibility to DN, but despite intensive research efforts the causative genes remain elusive. Recently, genome-wide association studies have discovered several novel genetic variants associated with DN. The identification of such variants may potentially allow for early identification of at risk patients. Here we review the current understanding of the key molecular mechanisms and genetic architecture of DN, and discuss the merits of employing an integrative approach to incorporate datasets from multiple sources (genetics, transcriptomics, epigenetic, proteomic) in order to fully elucidate the genetic elements contributing to this serious complication of diabetes.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Finian Martin, Catherine Godson, Denise Sadlier, Caitríona McEvoy, Eoin Brennan

Experts in our system

1
Finian Martin
University College Dublin
Total Publications: 81
 
2
Catherine Godson
University College Dublin
Total Publications: 93
 
3
Eoin P Brennan
University College Dublin
Total Publications: 18