Type

Journal Article

Authors

Lorraine Brennan
Eileen R Gibney
Michael J Gibney
Helen M. Roche
Miriam Ryan
Colm O'Grada
Ciara Morris

Subjects

Veterinary

Topics
metabolomic weight gain regulation amino acid insulin resistance bmi profiles amino acids

The relationship between BMI and metabolomic profiles: a focus on amino acids. (2012)

Abstract The role of metabolomics in the field of nutrition is continuing to grow and it has the potential to assist in the understanding of metabolic regulation and explain how minor perturbations can have a multitude of biochemical endpoints. It is this development, which creates the potential to provide the knowledge necessary to facilitate a more targeted approach to nutrition. In recent years, there has been interest in applying metabolomics to examine alterations in the metabolic profile according to weight gain/obesity. Emerging from these studies is the strong evidence that alterations in the amino acid (AA) profiles are associated with obesity. Several other studies have also shown a relationship between branched-chain amino acids (BCAA), obesity and insulin resistance. The present review focuses on the proposed link between AA and in particular BCAA, obesity and insulin resistance. In conclusion, a wealth of information is accumulating to support the role of AA, and in particular of the BCAA, in obesity.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Lorraine Brennan, Eileen R Gibney, Michael J Gibney, Helen M. Roche, Miriam Ryan, Colm O'Grada, Ciara Morris

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Eileen R Gibney
University College Dublin
Total Publications: 98
 
3
Michael J Gibney
University College Dublin
Total Publications: 102
 
4
Helen M. Roche
University College Dublin
Total Publications: 105
 
5
Miriam Ryan
University College Dublin
Total Publications: 34