Journal Article


Michael L. Doherty
Simon J More
Luke O'Grady
Nola Leonard
Eoin Gerard Ryan



irish population animals ireland cattle irish classification monoclonal antibody software tool leptospira

Seroprevalence of Leptospira Hardjo in the Irish suckler cattle population. (2011)

Abstract Prior to the present study, the seroprevalence of leptospirosis in Irish suckler herds was unknown. In this study, we describe the herd and animal-level prevalence of Leptospira Hardjo infection in the Irish suckler cattle population. For the purposes of the study, the 26 counties of the Republic of Ireland were divided into 6 regions from which a representative number of herds were selected. A herd was considered eligible for sampling if it was not vaccinating against leptospirosis and if it contained ≥ 9 breeding animals of beef breed ≥ 12 months of age. In total, 288 randomly selected herds were eligible for inclusion in the seroprevalence dataset analysis. Serological testing was carried out using a commercially available monoclonal antibody-capture ELISA, (sensitivity 100%; specificity 86.67%). Herds were categorised as either "Free from Infection" or "Infected" using the epidemiological software tool, FreeCalc 2.0. Using this classification, 237 herds were "Infected" (82.29%). The South West and South East regions had the highest herd prevalence. The regional effect on herd prevalence was largely mirrored by breeding herd size. A true animal-level prevalence of 41.75% was calculated using the epidemiological software tool, TruePrev. There was a statistically significant regional trend, with true prevalence being highest in the South East (P < 0.05). The median Breeding Herd Size (BHS), when categorised into quartiles, had a statistically significant influence on individual animal true seroprevalence (P < 0.001); true seroprevalence increased with increasing BHS. Leptospirosis is a widespread endemic disease in the Republic of Ireland. It is possible that economic losses due to leptospirosis in unvaccinated Irish suckler herds may be underestimated.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Michael L. Doherty, Simon J More, Luke O'Grady, Nola Leonard, Eoin Gerard Ryan

Experts in our system

Michael L. Doherty
Total Publications: 119
S J More
University College Dublin
Total Publications: 213
Luke O'Grady
University College Dublin
Total Publications: 54
Eoin Gerard Ryan
University College Dublin
Total Publications: 8