Type

Journal Article

Authors

Helen M. Roche
José López-Miranda
Christian A Drevon
Pablo Pérez-Martínez
Isobel C Gormley
Ingrid M F Gjelstad
Sinead Toomey
Hannelore Daniel
Ben van Ommen
Audrey C Tierney
and 1 others

Subjects

Microbiology

Topics
computational biology metabolism administration dosage humans oxidative stress gene expression metabolic networks and pathways adipose tissue genetics multivariate analysis adipogenesis fatty acids omega 3 models biological gene expression profiling health status promoter regions genetic

Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health. (2011)

Abstract Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis of a dataset of habitual dietary records, adipose tissue transcriptomics and comprehensive plasma marker profiles from human volunteers with the Metabolic Syndrome. With this approach we identified prominent co-expressed sub-networks in the global metabolic network, which showed correlated expression with habitual n-3 PUFA intake and urinary levels of the oxidative stress marker 8-iso-PGF(2α). These sub-networks illustrated inherent cross-talk between distinct metabolic pathways, such as between triglyceride metabolism and production of lipid signalling molecules. In a parallel promoter analysis, we identified several adipogenic transcription factors as potential transcriptional regulators associated with habitual n-3 PUFA intake. Our results illustrate advantages of network-based analysis, and generate novel hypotheses on the transcriptomic link between habitual n-3 PUFA intake, adipose tissue function and oxidative stress.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Helen M. Roche, José López-Miranda, Christian A Drevon, Pablo Pérez-Martínez, Isobel C Gormley, Ingrid M F Gjelstad, Sinead Toomey, Hannelore Daniel, Ben van Ommen, Audrey C Tierney and 1 others

Experts in our system

1
Helen M. Roche
University College Dublin
Total Publications: 105
 
2
José López-Miranda
University College Dublin
Total Publications: 18
 
3
Christian A Drevon
University College Dublin
Total Publications: 39
 
4
Pablo Pérez-Martínez
University College Dublin
Total Publications: 12
 
5
Ingrid M F Gjelstad
University College Dublin
Total Publications: 5
 
6
Sinead Toomey
Royal College of Surgeons in Ireland
Total Publications: 26
 
7
Hannelore Daniel
University College Dublin
Total Publications: 33
 
8
Audrey C Tierney
University College Dublin
Total Publications: 10