Journal Article


M J Duffy
A Pierce
E W McDermott
D Evoy
C Quinn
L Flanagan
S Walsh



mtor protein human breast neoplasms receptor erbb 2 middle aged receptors estrogen humans metabolism receptors progesterone immunohistochemistry erbb2 protein human tor serine threonine kinases female disease progression

mTOR in breast cancer: differential expression in triple-negative and non-triple-negative tumors. (2010)

Abstract Triple-negative breast cancer (TNBC) is defined by the absence of estrogen receptors (ER), progesterone receptors (PR) and overexpression of HER2. Targeted therapy is currently unavailable for this subgroup of breast cancer patients. mTOR controls cancer cell growth, survival and invasion and is thus a potential target for the treatment of patients with TNBC. Using immunohistochemistry, mTOR and p-mTOR were measured in 89 TNBCs and 99 non-TNBCs. While mTOR expression was confined to tumor cell cytoplasm, p-mTOR staining was located in the nucleus, perinuclear area and in the cytoplasm. Potentially important, was our finding that nuclear p-mTOR was found more frequently in triple-negative than non triple-negative cancers (p < 0.001). These results suggest that mTOR may play a more important role in the progression of TNBC compared to non-TNBC. Based on these findings, we conclude that mTOR may be a new target for the treatment of triple-negative breast cancer.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

M J Duffy, A Pierce, E W McDermott, D Evoy, C Quinn, L Flanagan, S Walsh

Experts in our system

Michael J Duffy
University College Dublin
E W McDermott
University College Dublin
Total Publications: 49
C M Quinn
University College Dublin
Total Publications: 11
S. W. Walsh
Total Publications: 21