Type

Journal Article

Authors

Mart C M De Jong
James O'Keeffe
Wayne Martin
Simon J More
Klaas Frankena
Eamonn Gormley
Leigh A L Corner
Denise Murphy
Guy McGrath
Inma Aznar

Subjects

Microbiology

Topics
ireland bcg vaccine prevalence transmission vaccination administration dosage tuberculosis vaccines models statistical mustelidae animals cattle prevention control microbiology immunology research design tuberculosis bovine veterinary randomized controlled trials as topic epidemiology incidence mycobacterium bovis

Trial design to estimate the effect of vaccination on tuberculosis incidence in badgers. (2011)

Abstract The principal wildlife reservoir of Mycobacterium bovis in Ireland is the European badger. Studies in the Republic of Ireland (RoI) have shown that badgers culled in association with cattle herd tuberculosis breakdowns (focal culling) have a higher prevalence of infection than the badger population at large. This observation is one rationale for the medium term national strategy of focal badger culling. A vaccination strategy for the control of bovine tuberculosis (bTB) in badgers is a preferred long-term option. The Bacillus Calmette-Guérin (BCG) vaccine has been shown to decrease disease severity in captive badgers under controlled conditions. As the vaccine has been tested in a controlled environment with precise information on infection pressure, it cannot be assumed a priori that the effects of vaccination are similar in the wild, where other environmental and/or ecological factors prevail. For this reason we have designed a vaccine field trial to assess the impact of vaccination on the incidence of TB infection in a wild badger population. The selected study area for the vaccine trial (approximately 755 square kilometers) is divided into three zones each of which has similar characteristics in terms of size, number of main badger setts, cattle herds, cattle and land classification type. Three vaccination levels (100%, 50% and 0%) will be allocated to the three zones in a way that a gradient of vaccination coverage North to South is achieved. The middle zone (zone B) will be vaccinated at a 50% coverage but zone A and C will be randomly allocated with 100% or 0% vaccination coverage. Vaccination within zone B will be done randomly at individual badger level. The objective of this paper is to describe the design of a field tuberculosis vaccination trial for badgers, the epidemiological methods that were used to design the trial and the subsequent data analysis. The analysis will enable us to quantify the magnitude of the observed vaccination effect on M. bovis transmission in badgers under field conditions and to improve our knowledge of the biological effects of vaccination on susceptibility and infectiousness.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Mart C M De Jong, James O'Keeffe, Wayne Martin, Simon J More, Klaas Frankena, Eamonn Gormley, Leigh A L Corner, Denise Murphy, Guy McGrath, Inma Aznar

Experts in our system

1
James O'Keeffe
University College Dublin
Total Publications: 48
 
2
S J More
University College Dublin
Total Publications: 171
 
3
Klaas Frankena
University College Dublin
Total Publications: 7
 
4
E Gormley
University College Dublin
Total Publications: 67
 
5
L A L Corner
University College Dublin
Total Publications: 34
 
6
Denise Murphy
University College Dublin
Total Publications: 13
 
7
Guy McGrath
University College Dublin
Total Publications: 46
 
8
I Aznar
University College Dublin
Total Publications: 9