Type

Journal Article

Authors

Lorraine Brennan
Fergus Shanahan
Albert Flynn
Kevin D. Cashman
Soniya Kaluskar
Brian Mion
Aine O Connor
Michael J Gibney
Aifric O'Sullivan

Subjects

Pharmacology

Topics
metabolic syndrome x adolescent metabolomics vitamin d administration dosage female dietary supplements metabolism diagnosis double blind method blood phenotype biological markers male analogs derivatives 25 hydroxyvitamin d humans middle aged adult

Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. (2010)

Abstract Metabolic phenotyping promises to be a useful tool in human intervention studies. This study examined whether metabolic phenotyping could identify responders to vitamin D supplementation in terms of the metabolic syndrome. In a double-blind, randomised placebo-controlled dietary intervention subjects were assigned to receive 15 μg vitamin D(3) or placebo daily. Serum 25-hydroxyvitamin D (25(OH)D) and biochemical markers of the metabolic syndrome were measured at baseline and following the 4-wk intervention. k-means clustering and (1) H-NMR metabolomic analysis were used to explore responsive phenotypes. Vitamin D supplementation significantly increased serum 25(OH)D to an endpoint concentration of 78.1 ± 20.0 nmol/L (p<0.001). There was no effect of supplementation on the measured markers of the metabolic syndrome. k-means cluster analysis based on 13 biochemical markers of the metabolic syndrome and 25(OH)D concentrations revealed five discrete biomarker clusters. One of these clusters, characterised by lower serum 25(OH)D and higher levels of adipokines, showed significant responses in insulin (15% decrease), homestatic model assessment scores (19% decrease) and c-reactive protein (54% decrease). Metabolomic analysis revealed further changes and the extent of change in serum vitamin D correlated negatively with changes in glucose. Overall, metabolic phenotyping revealed a phenotype that was responsive to vitamin D supplementation.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Lorraine Brennan, Fergus Shanahan, Albert Flynn, Kevin D. Cashman, Soniya Kaluskar, Brian Mion, Aine O Connor, Michael J Gibney, Aifric O'Sullivan

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Fergus Shanahan
University College Cork
Total Publications: 259
 
3
Albert Flynn
University College Cork
Total Publications: 83
 
4
Kevin D Cashman
University College Cork
Total Publications: 102
 
5
Michael J Gibney
University College Dublin
Total Publications: 102
 
6
Aifric O'Sullivan
University College Dublin
Total Publications: 11