Type

Journal Article

Authors

Lorraine Brennan
Michael J Gibney
Aifric O'Sullivan

Subjects

Chemistry

Topics
diet records analogs derivatives blood male young adult middle aged meat acetylcarnitine nutrition assessment metabolome urine vegetables diet magnetic resonance spectroscopy biological markers fatty acids energy intake adult glutamine phenylacetylglutamine humans adolescent female cluster analysis chromatography gas double blind method

Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies. (2010)

Abstract It has been suggested that metabolomics could play a role in dietary assessment and identification of novel biomarkers of dietary intake. This study examined the link between habitual dietary patterns and metabolomic profiles. A total of 160 volunteers participated in a double-blind, randomized, placebo-controlled dietary intervention. We collected biofluids and recorded 3-d food diaries. Food data were reduced to 33 food groups, and a k-means cluster analysis was performed to identify dietary patterns. (1)H Nuclear magnetic resonance (NMR) spectra were acquired for plasma and urine samples, and gas chromatography was used for plasma fatty acid profiling. Cluster analysis identified 3 distinct dietary patterns on the basis of the energy contribution of different food groups. Dietary clusters were reflected in plasma fatty acid profiles and in metabolomic data. (1)H NMR spectra of urine allowed the identification of metabolites associated with different dietary patterns. Several of the metabolites identified were linked to the intake of specific food groups; in particular, there was a positive association between O-acetylcarnitine and phenylacetylglutamine and red-meat and vegetable intakes, respectively. Habitual dietary patterns are shown in metabolomic data. This approach successfully identified potential biomarkers of red-meat and vegetable intakes.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Lorraine Brennan, Michael J Gibney, Aifric O'Sullivan

Experts in our system

1
Lorraine Brennan
University College Dublin
Total Publications: 166
 
2
Michael J Gibney
University College Dublin
Total Publications: 102
 
3
Aifric O'Sullivan
University College Dublin
Total Publications: 11