Type

Journal Article

Authors

P A J Brama
E W Hill
S Ennis
D. E. MacHugh
J A M van Arendonk
B Ducro
J Conroy
P Govindarajan
P Leegwater
J Gu
and 2 others

Subjects

Veterinary

Topics
animals horses genome wide association commercial availability snp association human gene localization

Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses. (2010)

Abstract The recent completion of the horse genome and commercial availability of an equine SNP genotyping array has facilitated the mapping of disease genes. We report putative localization of the gene responsible for dwarfism, a trait in Friesian horses that is thought to have a recessive mode of inheritance, to a 2-MB region of chromosome 14 using just 10 affected animals and 10 controls. We successfully genotyped 34,429 SNPs that were tested for association with dwarfism using chi-square tests. The most significant SNP in our study, BIEC2-239376 (P(2df)=4.54 × 10(-5), P(rec)=7.74 × 10(-6)), is located close to a gene implicated in human dwarfism. Fine-mapping and resequencing analyses did not aid in further localization of the causative variant, and replication of our findings in independent sample sets will be necessary to confirm these results.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

P A J Brama, E W Hill, S Ennis, D. E. MacHugh, J A M van Arendonk, B Ducro, J Conroy, P Govindarajan, P Leegwater, J Gu and 2 others

Experts in our system

1
P A J Brama
University College Dublin
Total Publications: 20
 
2
Emmeline W Hill
University College Dublin
Total Publications: 30
 
3
Sean Ennis
University College Dublin
Total Publications: 52
 
4
David E. MacHugh
University College Dublin
Total Publications: 80
 
5
Judith Conroy
University College Dublin
Total Publications: 24