Journal Article


Jennifer C McElwain
Cormac T. Taylor



adaptation physiological mixed function oxygenases procollagen proline dioxygenase physiology anaerobiosis humans physiopathology antagonists inhibitors animals biological evolution p300 cbp transcription factors transcription genetic anoxia cell hypoxia asparagine chemistry genetics metabolism hypoxia inducible factor 1 oxygen history ancient atmosphere

Ancient atmospheres and the evolution of oxygen sensing via the hypoxia-inducible factor in metazoans. (2010)

Abstract Metazoan diversification occurred during a time when atmospheric oxygen levels fluctuated between 15 and 30%. The hypoxia-inducible factor (HIF) is a primary regulator of the adaptive transcriptional response to hypoxia. Although the HIF pathway is highly conserved, its complexity increased during periods when atmospheric oxygen concentrations were increasing. Thus atmospheric oxygen levels may have provided a selection force on the development of cellular oxygen-sensing pathways.
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Full list of authors on original publication

Jennifer C McElwain, Cormac T. Taylor

Experts in our system

Jennifer C McElwain
University College Dublin
Total Publications: 25
Cormac T. Taylor
University College Dublin
Total Publications: 110