Type

Journal Article

Authors

Helen M. Roche
Richard Planells
Denis Lairon
Serge Hercberg
Ross Mcmanus
José López-Miranda
Ulf Risérus
Beata Kieć-Wilk
Ellen E Blaak
Christian A Drevon
and 9 others

Subjects

Microbiology

Topics
alleles obesity abdominal humans risk factors chemistry insulin resistance dietary fats genotype metabolic syndrome x genetics pathology metabolism fatty acids unsaturated administration dosage body mass index polymorphism genetic fatty acids acetyl coa carboxylase

ACC2 gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat. (2010)

Abstract Acetyl-CoA carboxylase β (ACC2) plays a key role in fatty acid synthesis and oxidation pathways. Disturbance of these pathways is associated with impaired insulin responsiveness and metabolic syndrome (MetS). Gene-nutrient interactions may affect MetS risk. This study determined the relationship between ACC2 polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). Minor A allele carriers of rs4766587 had increased MetS risk (OR 1.29 [CI 1.08, 1.58], P = 0.0064) compared with the GG homozygotes, which may in part be explained by their increased body mass index (BMI), abdominal obesity, and impaired insulin sensitivity (P < 0.05). MetS risk was modulated by dietary fat intake (P = 0.04 for gene-nutrient interaction), where risk conferred by the A allele was exacerbated among individuals with a high-fat intake (>35% energy) (OR 1.62 [CI 1.05, 2.50], P = 0.027), particularly a high intake (>5.5% energy) of n-6 polyunsaturated fat (PUFA) (OR 1.82 [CI 1.14, 2.94], P = 0.01; P = 0.05 for gene-nutrient interaction). Saturated and monounsaturated fat intake did not modulate MetS risk. Importantly, we replicated some of these findings in an independent cohort. In conclusion, the ACC2 rs4766587 polymorphism influences MetS risk, which was modulated by dietary fat, suggesting novel gene-nutrient interactions.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Helen M. Roche, Richard Planells, Denis Lairon, Serge Hercberg, Ross Mcmanus, José López-Miranda, Ulf Risérus, Beata Kieć-Wilk, Ellen E Blaak, Christian A Drevon and 9 others

Experts in our system

1
Helen M. Roche
University College Dublin
Total Publications: 105
 
2
Ross Mcmanus
Trinity College Dublin
 
3
José López-Miranda
University College Dublin
Total Publications: 18
 
4
Ulf Risérus
University College Dublin
 
5
Beata Kieć-Wilk
University College Dublin
Total Publications: 7
 
6
Ellen E Blaak
University College Dublin
Total Publications: 11
 
7
Christian A Drevon
University College Dublin
Total Publications: 39