Type

Journal Article

Authors

Helen M. Roche
José López-Miranda
Brita Karlstrom
Ulf Risérus
Beata Kieć-Wilk
Iwona Leszczyńska-Gołabek
Wim H M Saris
Ellen E Blaak
Christian A Drevon
Ingrid M F Gjelstad
and 8 others

Subjects

Biochemistry

Topics
risk factors metabolism nitric oxide synthase type iii humans middle aged dyslipidemias polymorphism genetic cardiovascular diseases female triglycerides genotype genetics fatty acids unsaturated nos3 protein human biological markers fatty acids omega 3 aged blood male metabolic syndrome x

NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids. (2009)

Abstract Omega-3 polyunsaturated fatty acids (n-3 PUFA) may protect against the development of cardiovascular disease (CVD). Genotype at key genes such as nitric oxide synthase (NOS3) may determine responsiveness to fatty acids. Gene-nutrient interactions may be important in modulating the development of CVD, particularly in high-risk individuals with the metabolic syndrome (MetS). Biomarkers of CVD risk, plasma fatty acid composition, and NOS3 single nucleotide polymorphism (SNP) genotype (rs11771443, rs1800783, rs1800779, rs1799983, rs3918227, and rs743507) were determined in 450 individuals with the MetS from the LIPGENE dietary intervention cohort. The effect of dietary fat modification for 12 weeks on metabolic indices of the MetS was determined to understand potential NOS3 gene-nutrient interactions. Several markers of inflammation and dyslipidaemia were significantly different between the genotype groups. A significant gene-nutrient interaction was observed between the NOS3 rs1799983 SNP and plasma n-3 PUFA status on plasma triacylglycerol (TAG) concentrations. Minor allele carriers (AC+AA) showed an inverse association with significantly higher plasma TAG concentrations in those with low plasma n-3 PUFA status and vice versa but the major allele homozygotes (CC) did not. Following n-3 PUFA supplementation, plasma TAG concentrations of minor allele carriers of rs1799983 were considerably more responsive to changes in plasma n-3 PUFA, than major allele homozygotes. Carriers of the minor allele at rs1799983 in NOS3 have plasma TAG concentrations which are more responsive to n-3 PUFA. This suggests that these individuals might show greater beneficial effects of n-3 PUFA consumption to reduce plasma TAG concentrations.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Helen M. Roche, José López-Miranda, Brita Karlstrom, Ulf Risérus, Beata Kieć-Wilk, Iwona Leszczyńska-Gołabek, Wim H M Saris, Ellen E Blaak, Christian A Drevon, Ingrid M F Gjelstad and 8 others

Experts in our system

1
Helen M. Roche
University College Dublin
Total Publications: 105
 
2
José López-Miranda
University College Dublin
Total Publications: 18
 
3
Ulf Risérus
University College Dublin
 
4
Beata Kieć-Wilk
University College Dublin
Total Publications: 7
 
5
Wim H M Saris
University College Dublin
Total Publications: 39
 
6
Ellen E Blaak
University College Dublin
Total Publications: 11
 
7
Christian A Drevon
University College Dublin
Total Publications: 39
 
8
Ingrid M F Gjelstad
University College Dublin
Total Publications: 5