Type

Journal Article

Authors

Helen M. Roche
José López-Miranda
Brita Karlstrom
Ulf Risérus
Beata Kieć-Wilk
Iwona Leszczynska-Golabek
Wim Hm Saris
Ellen E Blaak
Christian A Drevon
Ingrid Mf Gjelstad
and 10 others

Subjects

Microbiology

Topics
blood alleles male aged homozygote humans middle aged adult adiponectin dietary fats triglycerides insulin resistance female metabolic syndrome x case control studies fatty acids nonesterified waist circumference genetics receptors adiponectin fatty acids disease progression cross sectional studies polymorphism single nucleotide

Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. (2009)

Abstract Progression of the metabolic syndrome (MetS) is determined by genetic and environmental factors. Gene-environment interactions may be important in modulating the susceptibility to the development of MetS traits. Gene-nutrient interactions were examined in MetS subjects to determine interactions between single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and its receptors (ADIPOR1 and ADIPOR2) and plasma fatty acid composition and their effects on MetS characteristics. Plasma fatty acid composition, insulin sensitivity, plasma adiponectin and lipid concentrations, and ADIPOQ, ADIPOR1, and ADIPOR2 SNP genotypes were determined in a cross-sectional analysis of 451 subjects with the MetS who participated in the LIPGENE (Diet, Genomics, and the Metabolic Syndrome: an Integrated Nutrition, Agro-food, Social, and Economic Analysis) dietary intervention study and were repeated in 1754 subjects from the LIPGENE-SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) case-control study (http://www.ucd.ie/lipgene). Single SNP effects were detected in the cohort. Triacylglycerols, nonesterified fatty acids, and waist circumference were significantly different between genotypes for 2 SNPs (rs266729 in ADIPOQ and rs10920533 in ADIPOR1). Minor allele homozygotes for both of these SNPs were identified as having degrees of insulin resistance, as measured by the homeostasis model assessment of insulin resistance, that were highly responsive to differences in plasma saturated fatty acids (SFAs). The SFA-dependent association between ADIPOR1 rs10920533 and insulin resistance was replicated in cases with MetS from a separate independent study, which was an association not present in controls. A reduction in plasma SFAs could be expected to lower insulin resistance in MetS subjects who are minor allele carriers of rs266729 in ADIPOQ and rs10920533 in ADIPOR1. Personalized dietary advice to decrease SFA consumption in these individuals may be recommended as a possible therapeutic measure to improve insulin sensitivity. This trial was registered at clinicaltrials.gov as NCT00429195.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Helen M. Roche, José López-Miranda, Brita Karlstrom, Ulf Risérus, Beata Kieć-Wilk, Iwona Leszczynska-Golabek, Wim Hm Saris, Ellen E Blaak, Christian A Drevon, Ingrid Mf Gjelstad and 10 others

Experts in our system

1
Helen M. Roche
University College Dublin
Total Publications: 105
 
2
José López-Miranda
University College Dublin
Total Publications: 18
 
3
Ulf Risérus
University College Dublin
 
4
Beata Kieć-Wilk
University College Dublin
Total Publications: 7
 
5
Wim H M Saris
University College Dublin
Total Publications: 39
 
6
Ellen E Blaak
University College Dublin
Total Publications: 11
 
7
Christian A Drevon
University College Dublin
Total Publications: 39
 
8
Ingrid M F Gjelstad
University College Dublin
Total Publications: 5