Type

Journal Article

Authors

Mauricio S Krause
Colin Murphy
Giuseppe De Vito
Ciara O'Hagan
Paulo I Homem de Bittencourt
Philip Newsholme

Subjects

Pharmacology

Topics
prevention control physiopathology insulin secreting cells cardiovascular diseases insulin resistance diabetes mellitus type 2 reactive oxygen species physiology humans metabolism nitric oxide exercise hypertension

Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide. (2009)

Abstract It is now widely accepted that hypertension and endothelial dysfunction are associated with an insulin-resistant state and thus with the development of T2DM (Type 2 diabetes mellitus). Insulin signalling is impaired in target cells and tissues, indicating that common molecular signals are involved. The free radical NO* regulates cell metabolism, insulin signalling and secretion, vascular tone, neurotransmission and immune system function. NO* synthesis is essential for vasodilation, the maintenance of blood pressure and glucose uptake and, thus, if levels of NO* are decreased, insulin resistance and hypertension will result. Decreased blood levels of insulin, increased AngII (angiotensin II), hyperhomocysteinaemia, increased ADMA (asymmetric omega-NG,NG-dimethylarginine) and low plasma L-arginine are all conditions likely to decrease NO* production and which are associated with diabetes and cardiovascular disease. We suggest in the present article that the widely reported beneficial effects of exercise in the improvement of metabolic and cardiovascular health are mediated by enhancing the flux of muscle- and kidney-derived amino acids to pancreatic and vascular endothelial cells aiding the intracellular production of NO*, therefore resulting in normalization of insulin secretion, vascular tone and insulin sensitivity. Exercise may also have an impact on AngII and ADMA signalling and the production of pro- and anti-inflammatory cytokines in muscle, so reducing the progression and development of vascular disease and diabetes. NO* synthesis will be increased during exercise in the vascular endothelial cells so promoting blood flow. We suggest that exercise may promote improvements in health due to positive metabolic and cytokine-mediated effects.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Mauricio S Krause, Colin Murphy, Giuseppe De Vito, Ciara O'Hagan, Paulo I Homem de Bittencourt, Philip Newsholme

Experts in our system

1
Mauricio S Krause
Dublin City University
Total Publications: 8
 
2
Giuseppe De Vito
University College Dublin
Total Publications: 47
 
3
Philip Newsholme
University College Dublin
Total Publications: 51