Type

Journal Article

Authors

M J Duffy
N J O'Higgins
E W Mc Dermott
A D K Hill
P Diggin
R Cullen
G C Markey

Subjects

Medicine & Nursing

Topics
treatment outcome rna messenger lymphatic metastasis estrogen receptor alpha female time factors genetics neoplasm invasiveness survival analysis estrogen receptor beta proportional hazards models regression analysis pathology breast neoplasms humans mortality

Estrogen receptor-beta mRNA is associated with adverse outcome in patients with breast cancer. (2009)

Abstract Estrogen receptor (ER) is the prototype therapy predictive marker in oncology. The ER is now known to exist in two main forms with similar overall structure: ER-alpha and ER-beta. Both forms may be expressed in breast cancer. The aim of this study was to examine breast cancer outcome in relation to expression of ER-beta. In this investigation, we measured the expression of ER-alpha protein and ER-beta mRNA in 121 extracts of invasive breast cancer. Association of expression with clinical outcome was examined using Kaplan-Meier and Cox regression analyses. While ER-alpha expression was associated with good patient outcome [hazard ratio (HR) for death from breast cancer 0.37; 95% confidence interval (CI) 0.17-0.84; p = 0.017], ER-beta predicted poor outcome (HR for death from breast cancer 2.49; 95% CI 1.10-5.63; p = 0.028). Based on these findings, we conclude that ER-beta may have a different biological role from that of ER-alpha in breast cancer.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

M J Duffy, N J O'Higgins, E W Mc Dermott, A D K Hill, P Diggin, R Cullen, G C Markey

Experts in our system

1
Michael J Duffy
University College Dublin
 
2
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110