Type

Journal Article

Authors

J McNair
S Strain
P Andersen
C Milligan
D Corbett
J P Cassidy
M Welsh
G Mulcahy
R J Flynn

Subjects

Microbiology

Topics
interferon gamma transforming growth factor beta1 antigens helminth disease models animal interleukin 4 fasciola hepatica antigens bacterial autopsy immunology mycobacterium bovis fascioliasis cattle complications animals tuberculosis bovine veterinary metabolism random allocation biosynthesis antibodies helminth

Co-Infection of cattle with Fasciola hepatica and Mycobacterium bovis- immunological consequences. (2009)

Abstract Fasciola hepatica, the liver fluke, is a common parasite of cattle in much of the world. Previously, we have shown that cattle infected with F. hepatica have altered responsiveness (delayed type hypersensitivity reaction and cytokine responses) to M. bovis BCG infection. We hypothesized that co-infection with F. hepatica would, likewise, alter the immune response of cattle to virulent M. bovis infection, with possible implications for disease diagnosis and disease progression. Our previous work with F. hepatica/M. bovis BCG-infected cattle demonstrated a reduction in interferon (IFN)-gamma responsiveness in co-infected animals. Similar findings are reported here with virulent M. bovis following aerosol infection. The epidemiological significance of these findings, also, require exploration, particularly in view of the considerable resources devoted to the diagnosis and eradication of bovine tuberculosis, and the high prevalence of F. hepatica infection in areas where eradication has proved difficult.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

J McNair, S Strain, P Andersen, C Milligan, D Corbett, J P Cassidy, M Welsh, G Mulcahy, R J Flynn

Experts in our system

1
Joseph P. Cassidy
University College Dublin
Total Publications: 55
 
2
Michael D Welsh
Teagasc
Total Publications: 11
 
3
G Mulcahy
University College Dublin
Total Publications: 91