Type

Journal Article

Authors

Fionnuala B. Hickey
Catherine Godson
Madeline Murphy
Aidan Ryan

Subjects

Microbiology

Topics
diabetes mellitus animals apoptosis immunology humans inflammation cytokines physiopathology

Diabetes mellitus and apoptosis: inflammatory cells. (2009)

Abstract Since the early observation that similarities between thyroiditis and insulitis existed, the important role played by inflammation in the development of diabetes has been appreciated. More recently, experiments have shown that inflammation also plays a prominent role in the development of target organ damage arising as complications, with both elements of the innate and the adaptive immune system being involved, and that cytokines contributing to local tissue damage may arise from both infiltrating and resident cells. This review will discuss the experimental evidence that shows that inflammatory cell-mediated apoptosis contributes to target organ damage, from beta cell destruction to both micro- and macro-vascular disease complications, and also how alterations in leukocyte turnover affects immune function.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Fionnuala B. Hickey, Catherine Godson, Madeline Murphy, Aidan Ryan

Experts in our system

1
Fionnuala B. Hickey
Trinity College Dublin
Total Publications: 23
 
2
Catherine Godson
University College Dublin
Total Publications: 93
 
3
Madeline Murphy
University College Dublin
Total Publications: 37