Type

Journal Article

Authors

M J Duffy
J Crown
N O'Higgins
D Evoy
E W McDermott
A D K Hill
B M Ryan
F Bolster
E McKiernan
P M McGowan

Subjects

Biochemistry

Topics
enzymology prognosis adam proteins female biosynthesis humans middle aged enzyme linked immunosorbent assay mortality disease progression tumor necrosis factor alpha convertase breast neoplasms

ADAM-17 predicts adverse outcome in patients with breast cancer. (2008)

Abstract ADAM-17 is a matrix metalloproteinase-like enzyme involved in the release of several ligands that have been shown to promote both cancer formation and progression. These ligands include transforming growth factor-alpha, amphiregulin, heparin-binding epidermal growth factor, epiregulin and tumor necrosis factor-alpha. In this investigation, we measured the expression of total ADAM-17 by enzyme-linked immunosorbent assay in 153 invasive breast cancers. We also measured the precursor and active forms by western blotting in 140 invasive breast cancers. Expression of ADAM-17 was significantly increased in high-grade compared with low-grade tumors and was independent of tumor size, lymph node metastasis and estrogen receptor status. Patients with high expression of ADAM-17 had a significantly shorter overall survival compared with those with low expression. Significantly, the prognostic impact of ADAM-17 was independent of conventional prognostic factors for breast cancer. Our results are further evidence that ADAM-17 is involved in breast cancer progression and thus provides further impetus for exploiting ADAM-17 as new target for cancer treatment.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

M J Duffy, J Crown, N O'Higgins, D Evoy, E W McDermott, A D K Hill, B M Ryan, F Bolster, E McKiernan, P M McGowan

Experts in our system

1
Michael J Duffy
University College Dublin
 
2
John Crown
Dublin City University
Total Publications: 104
 
3
E W McDermott
University College Dublin
Total Publications: 49
 
4
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
 
5
Patricia M McGowan
Dublin City University
Total Publications: 8