Type

Journal Article

Authors

Stephen R Pennington
William M Gallagher
Neil R Kitteringham
Ambrose Clarke
Ben C Collins

Subjects

Microbiology

Topics
toxicology proteomics mass spectrometry isotope labeling biological markers chromatography liquid electrophoresis gel two dimensional animals humans

Use of proteomics for the discovery of early markers of drug toxicity. (2007)

Abstract Toxicity and safety issues remain a significant problem for drug development efforts by pharmaceutical and biotechnology companies. Exisiting early biomarkers of toxicity are insufficient and this is demonstrated by the high failure rate of candidate therapeutics due to toxicity problems. It is anticipated that the advent of 'omic' technologies should facilitate a comprehensive understanding of the perturbation of biological systems by toxic insults and, as such, will lead to better predictive models of toxicity for use in drug development. The field of proteomics continues to develop rapidly and it is already evident that proteomic approaches have much to contribute to the field of 'systems toxicology' and to the development of novel biomarkers of toxicity. Here, the key proteomic approaches are reviewed, their applications in pharmaceutical toxicology are described and what shape future developments in this arena might take is considered.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Stephen R Pennington, William M Gallagher, Neil R Kitteringham, Ambrose Clarke, Ben C Collins

Experts in our system

1
Stephen R Pennington
University College Dublin
 
2
William M Gallagher
University College Dublin
Total Publications: 148
 
3
Ben C Collins
University College Dublin
Total Publications: 8