Journal Article


A.C.O. Evans
J J Ireland
P M Coussens
G W Smith
P. Lonergan
M J Canty
M Rogers
N Forde



prions oligonucleotide array sequence analysis physiology ovary swine follicular fluid prpc proteins gene expression regulation reverse transcriptase polymerase chain reaction female ovarian follicle cattle animals genetics

Association of the prion protein and its expression with ovarian follicle development in cattle. (2007)

Abstract The cellular form of the prion protein (PrP(C)) has been detected in many tissues including reproductive tissues. While its function is unclear, it has been suggested to act as a receptor for an unidentified ligand and/or as an antioxidant agent. We tested the hypothesis that PrP(C) is differentially expressed in dominant, growing, compared to subordinate bovine ovarian follicles. Using both microarray analysis and quantitative real-time PCR, the level of prion protein mRNA (Prnp) in both theca and granulosa cells was measured. We found that levels of Prnp were significantly higher in the theca cells of dominant compared to subordinate follicles but similar among granulosa cells from different follicles. This difference was apparent immediately after selection of the dominant follicle and continued to the dominance stage of the follicle wave. Levels of the protein for PrP(C) were also higher (P < 0.05) in theca cells of dominant compared to subordinate follicles. In conclusion, elevated PrP(C) was associated with ovarian follicle growth and development and we suggest that it may play a role in the success of follicle development.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

A.C.O. Evans, J J Ireland, P M Coussens, G W Smith, P. Lonergan, M J Canty, M Rogers, N Forde

Experts in our system

A.C.O. Evans
University College Dublin
Total Publications: 92
P. Lonergan
University College Dublin
Total Publications: 190
N Forde
University College Dublin
Total Publications: 53