Type

Journal Article

Authors

M J Duffy
D J Slamon
J Crown
K C Podratz
M D Pegram
G Meng
M Untch
H-J Wang
S Kahlert
G E Konecny
and 1 others

Subjects

Biochemistry

Topics
female inhibitor of apoptosis proteins urokinase type plasminogen activator metabolism birc5 protein human treatment outcome plasminogen activator inhibitor 1 neoplasm proteins microtubule associated proteins breast neoplasms cohort studies receptor erbb 2 humans vascular endothelial growth factor a

Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1. (2006)

Abstract Survivin, a novel inhibitor of apoptosis, is one of the most cancer-specific proteins identified to date. In this study we (a) evaluated the association between survivin and HER2, vascular endothelial growth factor (VEGF) and uPA/PAI-1 expression and (b) defined its effect on clinical outcome in a large breast cancer patient cohort. Survivin expression was measured by ELISA in primary breast cancer tissue extracts from 420 patients with long-term clinical follow-up. Survivin was detected in 378 (90%) of the 420 primary breast cancer cases. Increased survivin levels were significantly associated with high nuclear grade (P < 0.0001), negative hormone receptor status (P = 0.0028), HER2 overexpression (P = 0.0094), VEGF expression (P < 0.0001), high uPA (P = 0.0002) and PAI-1 levels (P = 0.0002). Using the 25th percentile (1.4 ng/mg) as a cut-off point, patients expressing elevated survivin had a significantly worse disease-free survival (DFS: P = 0.0007, RR 1.97) and overall survival (OS: P = 0.0009, RR 2.11) compared with patients expressing lower levels of survivin. In multivariate analysis, this prognostic value of survivin was independent of both traditional and novel clinicopathologic factors for both DFS (P = 0.0076, RR 1.72) and OS (P = 0.0155, RR 1.76). The independent prognostic relevance of survivin, when combined with previous data from model systems implicating survivin in the inhibition of apoptosis, suggests that survivin may be a suitable target for future therapeutic strategies.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

M J Duffy, D J Slamon, J Crown, K C Podratz, M D Pegram, G Meng, M Untch, H-J Wang, S Kahlert, G E Konecny and 1 others

Experts in our system

1
Michael J Duffy
University College Dublin
 
2
John Crown
Dublin City University
Total Publications: 104