Type

Journal Article

Authors

William M Gallagher
Michael J Duffy
Desmond G Higgins
Aedín C Culhane
Ailís Fagan
Sallyann L O'Brien
Donal J Brennan

Subjects

Microbiology

Topics
combined modality therapy oligonucleotide array sequence analysis female breast neoplasms randomized controlled trials as topic genetics prognosis genetic therapy humans molecular biology therapy

Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response. (2005)

Abstract There are > 1.15 million cases of breast cancer diagnosed worldwide annually, and it is the second leading cause of cancer death in the European Union. The optimum management of patients with breast cancer requires accurate prognostic and predictive factors. At present, only a small number of such factors are used clinically. DNA microarrays have the potential to measure the expression of tens of thousands of genes simultaneously. Recent preliminary findings suggest that DNA microarray-based gene expression profiling can provide powerful and independent prognostic information in patients with newly diagnosed breast cancer. As well as providing prognostic information, emerging results suggest that DNA microarrays can also be used for predicting response or resistance to treatment, especially to neoadjuvant chemotherapy. Prior to clinical application, these preliminary findings must be validated using large-scale prospective studies. This article reviews these advances and also examines the role of DNA microarrays in reducing the number of patients who receive inappropriate chemotherapy. The most recent data supporting the integration of various publicly available data sets is also reviewed in detail.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

William M Gallagher, Michael J Duffy, Desmond G Higgins, Aedín C Culhane, Ailís Fagan, Sallyann L O'Brien, Donal J Brennan

Experts in our system

1
William M Gallagher
University College Dublin
Total Publications: 148
 
2
Michael J Duffy
University College Dublin
 
3
Desmond G Higgins
University College Dublin
Total Publications: 76
 
4
Ailís Fagan
Royal College of Surgeons in Ireland
Total Publications: 13
 
5
Donal J Brennan
University College Dublin