Journal Article


R William G Watson
David W Webb
John M Fitzpatrick
Margaret Sheridan-Pereira
Julie J Grantham
Amanda J O'Neill
Eleanor J Molloy



pharmacology labor obstetric cesarean section female apoptosis immunology pregnancy toll like receptor 4 lipopolysaccharides metabolism signal transduction toll like receptors tlr4 protein human cytology cell survival phenotype drug effects neutrophils delivery obstetric infant newborn vagina receptors cell surface membrane glycoproteins humans

Labor promotes neonatal neutrophil survival and lipopolysaccharide responsiveness. (2004)

Abstract Labor is a mild proinflammatory state that is associated with fetal leukocytosis. Elective cesarean section has been linked with increased neonatal morbidity, which may be partially immune mediated. We hypothesized that labor may alter neutrophil phenotype and thereby decrease neonatal complications. We characterized neutrophil function and survival in normal neonates after either uncomplicated vaginal delivery (VD) or elective cesarean section (CS) without labor. Spontaneous neutrophil apoptosis is delayed in cord blood neutrophils of neonates after normal labor (VD) compared with CS, as assessed by propidium iodide DNA incorporation using flow cytometry. This demonstrates their ability to maintain an inflammatory response. CD11b expression on neonatal neutrophils after CS is decreased, providing further evidence of altered activation or priming. Lipopolysaccharide responsiveness, characterized by CD11b and apoptosis, is similar in VD and adults, but CS-derived neutrophils are unresponsive. Baseline TLR-4 levels are elevated in CS in contrast to the other groups, although expression is not up-regulated by lipopolysaccharide co-incubation. Neonatal neutrophil survival and function are altered by labor and may increase antibacterial function and neutrophilia. This suggests that labor of any duration may be immunologically beneficial to the normal term neonate.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

R William G Watson, David W Webb, John M Fitzpatrick, Margaret Sheridan-Pereira, Julie J Grantham, Amanda J O'Neill, Eleanor J Molloy

Experts in our system

R William G Watson
University College Dublin
Total Publications: 135
David Webb
University College Dublin
Total Publications: 8
John M Fitzpatrick
University College Dublin
Total Publications: 129
Amanda J O'Neill
University College Dublin
Total Publications: 46
Eleanor J Molloy
TU Dublin (Tallaght Campus)
Total Publications: 22