Type

Journal Article

Authors

A D K Hill
N O'Higgins
E W McDermott
C M Quinn
T B Crotty
D Kavanagh
F J Fleming

Subjects

Medicine & Nursing

Topics
sentinel lymph node biopsy humans lymphatic metastasis neoplasm invasiveness female lymph node excision prospective studies axilla logistic models breast neoplasms aged aged 80 and over middle aged patient selection risk factors adult pathology

Factors affecting metastases to non-sentinel lymph nodes in breast cancer. (2003)

Abstract Because sentinel lymph node (SLN) biopsy for breast cancer has become well established, one of the challenges now is to determine which patients require a completion axillary dissection following a positive SLN biopsy. A prospective database of patients who underwent SLN biopsy for invasive breast cancer from July 1999 to November 2002 (n = 180) was analysed. Fifty four patients (30%) had one or more positive SLN, and all underwent a completion axillary dissection. This subgroup was further analysed to delineate which factors predicted non-SLN metastasis. Twenty six of the 54 patients with a positive SLN had additional metastases in non-SLNs. Significant variables that predicted non-SLN metastasis included extranodal extension (odds ratio (OR), 17.399; 95% confidence interval (CI), 1.69 to 178.96) and macrometastasis within the SLN (OR, 6.985; 95% CI, 1.291 to 37.785). In patients with invasive breast cancer and a positive SLN, extranodal extension or macrometastasis within the SLN were both independent predictors of non-SLN involvement.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

A D K Hill, N O'Higgins, E W McDermott, C M Quinn, T B Crotty, D Kavanagh, F J Fleming

Experts in our system

1
Arnold D K Hill
Royal College of Surgeons in Ireland
Total Publications: 110
 
2
E W McDermott
University College Dublin
Total Publications: 49
 
3
C M Quinn
University College Dublin
Total Publications: 11