Type

Journal Article

Authors

Carmel Hensey
Hugh R Brady
Pilar Alarcon
Madeline Murphy
Vincent Dolan

Subjects

Biochemistry

Topics
hypertrophy rats feedback physiological etiology diabetic nephropathies trans activators diabetes mellitus experimental hedgehog proteins animals kidney glomerulus mice mice knockout antagonists inhibitors bone morphogenetic proteins humans gene expression regulation disease progression genetics intercellular signaling peptides and proteins metabolism glomerulosclerosis focal segmental nephritis interstitial kidney diseases fibrosis grem1 protein human physiology physiopathology dimerization kidney failure chronic

Gremlin - a putative pathogenic player in progressive renal disease. (2003)

Abstract Progressive renal fibrosis is the end process of renal injury leading to kidney failure. Current therapies for chronic renal failure aim to slow this process but fail to halt its progression. As the mechanisms involved in glomerulosclerosis and tubulointerstitial fibrosis are unravelled, potential treatments for this growing clinical problem should emerge. Gremlin, a developmental regulator of bone morphogenetic proteins (BMPs), has recently been implicated in processes such as glomerulosclerosis, tubulointerstitial fibrosis and cellular hypertrophy, and may represent a novel therapeutic target in progressive renal diseases.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Carmel Hensey, Hugh R Brady, Pilar Alarcon, Madeline Murphy, Vincent Dolan

Experts in our system

1
Madeline Murphy
University College Dublin
Total Publications: 37