Type

Journal Article

Authors

Hugh R Brady
David W P Lappin
Ruth McMahon
Madeline Murphy

Subjects

Biochemistry

Topics
proteins glomerulosclerosis focal segmental nephritis interstitial kidney grem1 protein human intercellular signaling peptides and proteins physiology animals physiopathology humans embryology

Gremlins: is this what renal fibrogenesis has come to? (2002)

Abstract Gremlin is a member of the differential screening-selected gene aberrative in the neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists. Gremlin influences diverse processes in growth, differentiation and development. Increased expression of gremlin has recently been demonstrated in several models of diabetic nephropathy. Gremlin arrests the cell cycle in mesangial cells and has also been shown to be upregulated in transdifferentiated renal proximal tubular cells. This review summarizes emerging evidence implicating gremlin in the pathophysiology of glomerulosclerosis and tubulointerstitial fibrosis. Gremlin is a potential novel therapeutic target in progressive renal diseases.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

Hugh R Brady, David W P Lappin, Ruth McMahon, Madeline Murphy

Experts in our system

1
Madeline Murphy
University College Dublin
Total Publications: 37