Type

Journal Article

Authors

K Sheahan
D P O'Donoghue
N A Parfrey
P McCarthy
D Gibbons
M J Duffy
H E Mulcahy

Subjects

Medicine & Nursing

Topics
humans mortality survival rate immunohistochemistry chemistry prognosis colorectal neoplasms urokinase type plasminogen activator tumor markers biological aged aged 80 and over middle aged adult pathology

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer. (1994)

Abstract Urokinase-type plasminogen activator (u-PA) is a serine protease involved in cancer metastasis. Using immunohistochemical methods, we examined the relation between u-PA and long-term survival in 70 patients with Dukes' B colorectal cancer. 8-year survival was 81% in patients whose tumours demonstrated low-grade epithelial u-PA staining and 43% in those with high-grade staining (log-rank test, p = 0.01). Survival was unrelated to stromal u-PA staining. These results suggest that u-PA may be useful in the identification of patients with non-metastatic colorectal cancer at risk of tumour recurrence.
Collections Ireland -> University College Dublin -> PubMed

Full list of authors on original publication

K Sheahan, D P O'Donoghue, N A Parfrey, P McCarthy, D Gibbons, M J Duffy, H E Mulcahy

Experts in our system

1
Kieran Sheahan
University College Dublin
Total Publications: 40
 
2
Diarmuid O'Donoghue
University College Dublin
Total Publications: 42
 
3
David Gibbons
University College Dublin
Total Publications: 8
 
4
Michael J Duffy
University College Dublin
 
5
Hugh E Mulcahy
University College Dublin
Total Publications: 43