Type

Journal Article

Authors

Michael Fitzgerald
Mark Bellgrove
Michael Gill
Louise Gallagher
Ian Robertson
Katherine Johnson

Subjects

Psychiatry

Topics
response time sustained attention response inhibition neuropsychiatry disorder adhd variability neurodevelopmental psychiatry child psychiatry community psychiatry psychiatry attention deficit hyperactivity disorder adhd adolescent psychiatry general hospital psychiatry consultation liaison psychiatry add adhd executive function fast fourier transform liaison psychiatry child and adolescent psychiatry neuroscience adhd arousal

Dissociation in performance of children with ADHD and autism on a task of sustained attention (2007)

Abstract (242) PMID: 17433378 ABSTRACT: Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal circuits. We probed executive function in these disorders using a sustained attention task with a validated brain-behaviour basis. Twenty-three children with ADHD, 21 children with high-functioning autism (HFA) and 18 control children were tested on the Sustained Attention to Response Task (SART). In a fixed sequence version of the task, children were required to withhold their response to a predictably occurring no-go target (3) in a 1-9 digit sequence; in the random version the sequence was unpredictable. The ADHD group showed clear deficits in response inhibition and sustained attention, through higher errors of commission and omission on both SART versions. The HFA group showed no sustained attention deficits, through a normal number of omission errors on both SART versions. The HFA group showed dissociation in response inhibition performance, as indexed by commission errors. On the Fixed SART, a normal number of errors was made, however when the stimuli were randomised, the HFA group made as many commission errors as the ADHD group. Greater slow-frequency variability in response time and a slowing in mean response time by the ADHD group suggested impaired arousal processes. The ADHD group showed greater fast-frequency variability in response time, indicative of impaired top-down control, relative to the HFA and control groups. These data imply involvement of fronto-parietal attentional networks and sub-cortical arousal systems in the pathology of ADHD and prefrontal cortex dysfunction in children with HFA.
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Full list of authors on original publication

Michael Fitzgerald, Mark Bellgrove, Michael Gill, Louise Gallagher, Ian Robertson, Katherine Johnson

Experts in our system

1
Michael Fitzgerald
Trinity College Dublin
Total Publications: 90
 
2
Mark A. Bellgrove
Trinity College Dublin
Total Publications: 35
 
3
Michael Gill
Trinity College Dublin
Total Publications: 260
 
4
Louise Gallagher
Trinity College Dublin
Total Publications: 55
 
5
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
6
Katherine Johnson
Trinity College Dublin
Total Publications: 29