Journal Article


Michael D Gilchrist
Aoife Smyth
William T. O'Connor


Medicine & Nursing

microdialysis animals disease models animal models neurological instrumentation validation studies as topic nerve degeneration diagnosis pathology humans brain injuries

Animal models of traumatic brain injury: a critical evaluation. (2010)

Abstract Animal models are necessary to elucidate changes occurring after brain injury and to establish new therapeutic strategies towards a stage where drug efficacy in brain injured patients (against all classes of symptoms) can be predicted. In this review, six established animal models of head trauma, namely fluid percussion, rigid indentation, inertial acceleration, impact acceleration, weight-drop and dynamic cortical deformation are evaluated. While no single animal model is entirely successful in reproducing the complete spectrum of pathological changes observed after injury, the validity of these animal models including face, construct, etiological and construct validity and how the models constitute theories about brain injury is addressed. The various types of injury including contact (direct impact) and non-contact (acceleration/deceleration) and their associated pathologies are described. The neuropathologic classifications of brain injury including primary and secondary, focal and diffuse are discussed. Animal models and their compatibility with microdialysis studies are summarised particularly regarding the role of excitatory and inhibitory amino acid neurotransmitters. This review concludes that the study of neurotransmitter interactions within and between brain regions can facilitate the development of novel compounds targeted to treat those cognitive deficits not limited to a single pharmacological class and may be useful in the investigation of new therapeutic strategies and pharmacological testing for improved treatment for traumatic head injury.
Collections Ireland -> University of Limerick -> PubMed

Full list of authors on original publication

Michael D Gilchrist, Aoife Smyth, William T. O'Connor

Experts in our system

M. D. Gilchrist
University College Dublin
Total Publications: 172
William T. O'Connor
University College Dublin
Total Publications: 21