Type

Journal Article

Authors

John J Foxe
Hugh Garavan
Robert Hester
Michael Fitzgerald
Adam Lau
Paul Dockree
Mark A Bellgrove
Ian Robertson
Redmond G O'Connell

Subjects

Psychiatry

Topics
female error awareness awareness pathology adult adhd adhd lifetime impairment survey male evoked potentials young adult adhd disorder adhd physiology child psychiatry erp brain mapping anterior cingulate cortex adolescent psychiatry neuropsychological tests neuroscience psychiatry consultation liaison psychiatry liaison psychiatry international multicentre adhd genetics project cognition disorders complications attention deficit disorder with hyperactivity electroencephalography trainees in psychiatry etiology child and adolescent psychiatry deficient error awareness source analysis neuropsychiatry humans community psychiatry adolescent reaction time attention deficit hyperactivity disorder adhd analysis of variance decision making general hospital psychiatry add adhd neural correlates

The neural correlates of deficient error awareness in attention-deficit hyperactivity disorder (ADHD) (2009)

Abstract (272) . PMID: 19350709 ABSTRACT: The ability to detect and correct errors is critical to adaptive control of behaviour and represents a discrete neuropsychological function. A number of studies have highlighted that attention-deficit hyperactivity disorder (ADHD) is associated with abnormalities in behavioural and neural responsiveness to performance errors. One limitation of previous work has been a failure to determine the extent to which these differences are attributable to failures of conscious error awareness, a process that is dependent on the integrity of the frontal lobes. Recent advances in electrophysiological research make it possible to distinguish unconscious and conscious aspects of error processing. This study constitutes an extensive electrophysiological investigation of error awareness and error processing in ADHD. A Go/No-Go response inhibition task specifically designed to assess error awareness was administered to a group of adults diagnosed with ADHD and a group of matched control participants. The ADHD group made significantly more errors than the control group but was less likely to consciously detect these errors. An analysis of event-related potentials elicited by errors indicated that an early performance monitoring component (early positivity) was significantly attenuated in the ADHD group as was a later component that specifically reflects conscious error processing (Pe). Dipole source modelling suggested that abnormal Pe amplitudes were attributable to decreased activation of the anterior cingulate cortex. Decreased electrodermal activity in the ADHD group also suggested a motivational insensitivity to performance errors. Our data provide evidence that neuropsychological deficits associated with ADHD can be exacerbated by error processing abnormalities. Error awareness may represent an important cognitive and physiological phenotype for ADHD.
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Full list of authors on original publication

John J Foxe, Hugh Garavan, Robert Hester, Michael Fitzgerald, Adam Lau, Paul Dockree, Mark A Bellgrove, Ian Robertson, Redmond G O'Connell

Experts in our system

1
John J Foxe
Trinity College Dublin
Total Publications: 44
 
2
Hugh Garavan
Trinity College Dublin
Total Publications: 170
 
3
Michael Fitzgerald
Trinity College Dublin
Total Publications: 101
 
4
Paul M Dockree
Trinity College Dublin
Total Publications: 35
 
5
Mark A. Bellgrove
Trinity College Dublin
Total Publications: 39
 
6
Ian H Robertson
Trinity College Dublin
Total Publications: 162
 
7
Redmond G O'Connell
Trinity College Dublin
Total Publications: 59