Type

Journal Article

Authors

Maeve A. Mangaoang
Sunita Sukumaran
Julie Prendergast
Deirdre McMackin
Mary Fitzsimons
Judy Hayden
Paul Brennan
Shane O'Mara
Jonathan P. McNulty
Ian Robertson
and 3 others

Subjects

Psychology

Topics
neuronal plasticity long memory psychology hippocampus human facilitation learning and memory magnetic resonance spectroscopy brain ageing

Prolonged rote learning produces delayed memory facilitation and metabolic changes in the hippocampus of the ageing human brain (2009)

Abstract Background: Repeated rehearsal is one method by which verbal material may be transferred from short- to long-term memory. We hypothesised that extended engagement of memory structures through prolonged rehearsal would result in enhanced efficacy of recall and also of brain structures implicated in new learning. Twenty-four normal participants aged 55-70 (mean = 60.1) engaged in six weeks of rote learning, during which they learned 500 words per week every week (prose, poetry etc.). An extensive battery of memory tests was administered on three occasions, each six weeks apart. In addition, proton magnetic resonance spectroscopy (1H-MRS) was used to measure metabolite levels in seven voxels of interest (VOIs) (including hippocampus) before and after learning. Results: Results indicate a facilitation of new learning that was evident six weeks after rote learning ceased. This facilitation occurred for verbal/episodic material only, and was mirrored by a metabolic change in left posterior hippocampus, specifically an increase in NAA/(Cr+Cho) ratio. Conclusion: Results suggest that repeated activation of memory structures facilitates anamnesis and may promote neuronal plasticity in the ageing brain, and that compliance is a key factor in such facilitation as the effect was confined to those who engaged fully with the training.
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Ireland -> National University of Ireland Maynooth -> Type = Article
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Full list of authors on original publication

Maeve A. Mangaoang, Sunita Sukumaran, Julie Prendergast, Deirdre McMackin, Mary Fitzsimons, Judy Hayden, Paul Brennan, Shane O'Mara, Jonathan P. McNulty, Ian Robertson and 3 others

Experts in our system

1
Shane Michael O'Mara
Trinity College Dublin
Total Publications: 56
 
2
Jonathan P McNulty
Trinity College Dublin
Total Publications: 10
 
3
Ian H Robertson
Trinity College Dublin
Total Publications: 142