Journal Article


Michael Gill
Aisling Mulligan
Ziarih Hawi
Hugh Garavan
Ian Robertson
Edwina Barry
Katherine Johnson



adhd response inhibition genetic variation dat1 dopamine transporter neuroscience executive functioning error processing

fMRI activation during response inhibition and error processing: the role of the DAT1 gene in typically developing adolescents and those diagnosed with ADHD (2011)

Abstract The DAT1 gene codes for the dopamine transporter, which clears dopamine from the synaptic cleft, and a variant of this gene has previously been associated with compromised response inhibition in both healthy and clinical populations. This variant has also been associated with ADHD, a disorder that is characterised by disturbed dopamine function as well as problems with response inhibition. In the present study we used fMRI to investigate the role of dopaminergic genetic variation on executive functioning by comparing how activation associated with successful and unsuccessful inhibitions differs based on DAT1-genotype and ADHD-diagnosis in adolescents performing a go/nogo task. The results identify regional specificity concerning which functional differences can be attributed to the possession of the high risk DAT1 genotype, the clinical condition or an interaction between the two. During response inhibition, individuals with two copies of the 10-repeat allele showed increased activation in frontal, medial, and parietal regions, which may indicate that inhibition is more effortful for this group. Conversely, this group displayed a reduced error response in the parahippocampal gyrus, suggestive of reduced learning from errors. There were also a number of frontal, parietal, medial and occipital regions, where the relationship between genotype and fMRI-activation differed between the ADHD group and typically developing adolescents. Finally, the ADHD group displayed decreased activation in parietal and (pre)frontal regions during response inhibition, and in frontal and medial brain regions on error trials.
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Full list of authors on original publication

Michael Gill, Aisling Mulligan, Ziarih Hawi, Hugh Garavan, Ian Robertson, Edwina Barry, Katherine Johnson

Experts in our system

Michael Gill
Trinity College Dublin
Total Publications: 294
Aisling Mulligan
Trinity College Dublin
Total Publications: 11
Hugh Garavan
Trinity College Dublin
Total Publications: 170
Ian H Robertson
Trinity College Dublin
Total Publications: 162
Katherine Johnson
Trinity College Dublin
Total Publications: 29