Journal Article


M. D. Gilchrist
William O'Connor
Olivier L. Gobbo
Michelle M. Cronin
Shane Michael O'Mara
Niall C. Colgan



male organ size disease models animal traumatic brain injury brain trauma physiology brain damage animal models neuroscience animals cerebral cortex time factors etiology rats brain injuries brain brain edema rats sprague dawley animal studies glasgow coma scale magnetic resonance imaging impact analysis rat quantitative analysis physiopathology mri central nervous system injuries diagnosis disease progression

Quantitative MRI analysis of brain volume changes due to controlled cortical impact. (2010)

Abstract More than 85% of reported brain traumas are classified clinically as "mild" using the Glasgow Coma Scale (GCS); qualitative MRI findings are scarce and provide little correspondence to clinical symptoms. Our goal, therefore, was to establish in vivo sequelae of traumatic brain injury (TBI) following lower and higher levels of impact to the frontal lobe using quantitative MRI analysis and a mechanical model of penetrating impact injury. To investigate time-based morphological and physiological changes of living tissue requires a surrogate for the human central nervous system. The present model for TBI was a systematically varied and controlled cortical impact on deeply-anaesthetized Sprague-Dawley rats, that was designed to mimic different injury severities. Whole-brain MRI scans were performed on each rat prior to either a lower- or a higher-level of impact, and then at hourly intervals for 5 h post-impact. Both brain volume and specific anatomical structures were segmented from MR images for inter-subject comparisons post-registration. Animals subjected to lower and higher impact levels exhibited elevated intracranial pressure (ICP) in the low compensatory reserve (i.e., nearly exhausted), and terminal disturbance (i.e., exhausted) ranges, respectively. There was a statistically significant drop in cerebrospinal fluid (CSF) of 35% in the lower impacts, and 65% in the higher impacts, at 5 h compared to sham controls. There was a corresponding increase in corpus callosum volume starting at 1 h, of 60-110% and 30-40% following the lower- and higher-impact levels, respectively. A statistically significant change in the abnormal tissue from 2 h to 5 h was observed for both impact levels, with greater significance for higher impacts. Furthermore, a statistically significant difference between the lower impacts and the sham controls occurred at 3 h. These results are statistically substantiated by a fluctuation in the physical size of the corpus callosum, a decrease in the volume of CSF, and elevated levels of atrophy in the cerebral cortex.
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Full list of authors on original publication

M. D. Gilchrist, William O'Connor, Olivier L. Gobbo, Michelle M. Cronin, Shane Michael O'Mara, Niall C. Colgan

Experts in our system

M. D. Gilchrist
University College Dublin
Total Publications: 172
William T. O'Connor
University College Dublin
Total Publications: 21
Shane Michael O'Mara
Trinity College Dublin
Total Publications: 63