Type

Journal Article

Authors

Maria Santos-Martinez
Carlos Medina Martin
Owen Corrigan
Lidia Tajber

Subjects

Chemistry

Topics
self assembled immunology inflammation infection nanotechnology biomedical applications of nanotechnology pharmacy nanoscience materials drug delivery systems peptide synthesis

Self-Assembled Hyaluronate/Protamine Polyelectrolyte Nanoplexes: Synthesis, Stability, Biocompatibility and Potential Use as Peptide Carriers (2014)

Abstract This work investigates a new type of polyelectrolyte complex nanocarrier composed of hyaluronic acid (HA) and protamine (PROT). Small (approximately 60 nm) and negatively charged nanoparticles (NPs) with a polydispersity index of less than 0.2 were obtained with properties that were dependent on the mixing ratio, concentration of polyelectrolytes and molecular weight of HA. Salmon calcitonin (sCT) was efficiently (up to 100%) associated with the NPs, and the drug loading (9.6-39% w/w) was notably high, possibly due to an interaction between HA and sCT. The NPs released -70-80% of the sCT after 24 hours, with the estimated total amount of released sCT depending on the amount of HA and PROT present in the NPs. The isoelectric point of the NPs was close to pH 2, and the negative surface charge was maintained above this pH. The HA/PROT nanoplexes protected the sCT from enzymatic degradation and showed low toxicity to intestinal epithelial cells, and thus may be a promising oral delivery system for peptides.
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Full list of authors on original publication

Maria Santos-Martinez, Carlos Medina Martin, Owen Corrigan, Lidia Tajber

Experts in our system

1
Maria Jose Santos-Martinez
Trinity College Dublin
Total Publications: 29
 
2
Carlos Medina Martin
Trinity College Dublin
Total Publications: 28
 
3
Owen I. Corrigan
Trinity College Dublin
Total Publications: 66
 
4
Lidia Tajber
Trinity College Dublin
Total Publications: 83