Type

Journal Article

Authors

Shane Michael O'Mara
Robert Coen
Brian Lawlor

Subjects

Psychiatry

Topics
neuroscience follow up episodic memory longitudinal studies mild cognitive impairment alzheimer s disease ad learning and memory logistic regression

Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation (2011)

Abstract Background: Decline in episodic memory is one of the hallmark features of Alzheimer's disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of AD. While deficits in episodic memory are well documented in MCI, the nature of this impairment remains relatively under-researched, particularly for those domains with direct relevance and meaning for the patient's daily life. In order to fully explore the impact of disruption to the episodic memory system on everyday memory in MCI, we examined participants' episodic memory capacity using a battery of experimental tasks with real-world relevance. We investigated episodic acquisition and delayed recall (story-memory), associative memory (face-name pairings), spatial memory (route learning and recall), and memory for everyday mundane events in 16 amnestic MCI and 18 control participants. Furthermore, we followed MCI participants longitudinally to gain preliminary evidence regarding the possible predictive efficacy of these real-world episodic memory tasks for subsequent conversion to AD. Results: The most discriminating tests at baseline were measures of acquisition, delayed recall, and associative memory, followed by everyday memory, and spatial memory tasks, with MCI patients scoring significantly lower than controls. At follow-up (mean time elapsed: 22.4 months), 6 MCI cases had progressed to clinically probable AD. Exploratory logistic regression analyses revealed that delayed associative memory performance at baseline was a potential predictor of subsequent conversion to AD. Conclusions: As a preliminary study, our findings suggest that simple associative memory paradigms with real-world relevance represent an important line of enquiry in future longitudinal studies charting MCI progression over time.
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Full list of authors on original publication

Shane Michael O'Mara, Robert Coen, Brian Lawlor

Experts in our system

1
Shane Michael O'Mara
Trinity College Dublin
Total Publications: 65
 
2
Robert F Coen
Trinity College Dublin
Total Publications: 35
 
3
Brian A. Lawlor
National College Ireland
Total Publications: 125