Type

Journal Article

Authors

Andrew Lloyd
Mario Fares
Cliona O'Farrelly

Subjects

Microbiology

Topics
pressure mammalian antimicrobial peptides immune response sites immunology inflammation infection alpha defensins maximum likelihood family

Evidence of positively selected sites in mammalian alpha-defensins. (2004)

Abstract Alpha-defensins are a family of mammalian antimicrobial peptides that exhibit variable activity against a panel of microbes, including bacteria, fungi, and enveloped viruses. We have employed a maximum-likelihood approach to detect evidence of positive selection (adaptive evolution) in the evolution of these important molecules of the innate immune response. We have identified 14 amino acid sites that are predicted to be subject to positive selection. Furthermore, we show that all these sites are located in the mature antimicrobial peptide and not in the prepropeptide region of the molecule, implying that they are of functional importance. These results suggest that mammalian alpha-defensins have been under selective pressure to evolve in response to potentially infectious challenges by fast-evolving microbes.
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Full list of authors on original publication

Andrew Lloyd, Mario Fares, Cliona O'Farrelly

Experts in our system

1
Andrew T. Lloyd
Trinity College Dublin
Total Publications: 17
 
2
Mario Ali Fares
Trinity College Dublin
Total Publications: 43
 
3
Cliona O'Farrelly
Trinity College Dublin
Total Publications: 126