Type

Journal Article

Authors

Arun Lawrence Warren Bokde
Hugh Patrick Garavan
Aiden Peter Corvin
Gary (James) Donohoe
Daniela Tropea
Michael Gill
John Philip O'Doherty
Jane Mcgrath
Fiona Newell
Ian H Robertson
and 5 others

Subjects

Psychiatry

Topics
young adult magnetic resonance imaging polymorphism single nucleotide humans adult voxel based morphometry brain function genotype schizophrenia white matter alleles female spatial working memory physiopathology genetic predisposition to disease genetics genome wide association studies memory short term pathology neurogranin brain male

The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function. (2012)

Abstract A single nucleotide polymorphism rs12807809 located upstream of the neurogranin (NRGN) gene has been identified as a risk variant for schizophrenia in recent genome-wide association studies. To date, there has been little investigation of the endophenotypic consequences of this variant, and our own investigations have suggested that the effects of this gene are not apparent at the level of cognitive function in patients or controls. Because the impact of risk variants may be more apparent at the level of brain, the aim of this investigation was to delineate whether NRGN genotype predicted variability in brain structure and/or function. Healthy individuals participated in structural (N = 140) and/or functional (N = 36) magnetic resonance imaging (s/fMRI). Voxel-based morphometry was used to compare gray and white matter volumes between carriers of the non-risk C allele (i.e., CC/CT) and those who were homozygous for the risk T allele. Functional imaging data were acquired during the performance of a spatial working memory task, and were also analyzed with respect to the difference between C carriers and T homozygotes. There was no effect of the NRGN variant rs12807809 on behavioral performance or brain structure. However, there was a main effect of genotype on brain activity during performance of the working memory task, such that while C carriers exhibited a load-independent decrease in left superior frontal gyrus/BA10, TT individuals failed to show a similar decrease in activity. The failure to disengage this ventromedial prefrontal region, despite preserved performance, may be indicative of a reduction in processing efficiency in healthy TT carriers. Although it remains to be established whether this holds true in larger samples and in patient cohorts, if valid, this suggests a potential mechanism by which NRGN variability might contribute to schizophrenia risk.
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Full list of authors on original publication

Arun Lawrence Warren Bokde, Hugh Patrick Garavan, Aiden Peter Corvin, Gary (James) Donohoe, Daniela Tropea, Michael Gill, John Philip O'Doherty, Jane Mcgrath, Fiona Newell, Ian H Robertson and 5 others

Experts in our system

1
Arun L W Bokde
Trinity College Dublin
Total Publications: 76
 
2
Hugh Garavan
Trinity College Dublin
Total Publications: 160
 
3
Aiden Corvin
Trinity College Dublin
Total Publications: 190
 
4
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
5
Daniela Tropea
Trinity College Dublin
Total Publications: 25
 
6
Michael Gill
Trinity College Dublin
Total Publications: 260
 
7
John P O'Doherty
Trinity College Dublin
Total Publications: 19
 
8
Jane Mcgrath
Trinity College Dublin
Total Publications: 11
 
9
Fiona N. Newell
Trinity College Dublin
Total Publications: 54
 
10
Ian H Robertson
Trinity College Dublin
Total Publications: 142