Type

Journal Article

Authors

Angela Carballedo
Thomas Frodl
Andrew Fagan
James Meaney

Subjects

Psychiatry

Topics
major depressive disorder mdd magnetic resonance imaging mri childhood maltreatment neuroscience sample size childhood abuse high resolution voxel based morphometry prefrontal cortex

Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants. (2014)

Abstract BACKGROUND: Childhood maltreatment has been found to play a crucial role in the development of psychiatric disorders. However, whether childhood maltreatment is associated with structural brain changes described for major depressive disorder (MDD) is still a matter of debate. The aim of this study was to investigate whether patients with MDD and a history of childhood maltreatment display more structural changes than patients without childhood maltreatment or healthy controls. METHODS: Patients with MDD and healthy controls with and without childhood maltreatment experience were investigated using high-resolution magnetic resonance imaging (MRI), and data were analyzed using voxel-based morphometry. RESULTS: We studied 37 patients with MDD and 46 controls. Grey matter volume was significantly decreased in the hippocampus and significantly increased in the dorsomedial prefrontal cortex (DMPFC) and the orbitofrontal cortex (OFC) in participants who had experienced childhood maltreatment compared with those who had not. Patients displayed smaller left OFC and left DMPFC volumes than controls. No significant difference in hippocampal volume was evident between patients with MDD and healthy controls. In regression analyses, despite effects from depression, age and sex on the DMPFC, OFC and hippocampus, childhood maltreatment was found to independently affect these regions. LIMITATIONS: The retrospective assessment of childhood maltreatment; the natural problem that patients experienced more childhood maltreatment than controls; and the restrictions, owing to sample size, to investigating higher order interactions among factors are discussed as limitations. CONCLUSION: These results suggest that early childhood maltreatment is associated with brain structural changes irrespective of sex, age and a history of depression.Thus, the study highlights the importance of childhood maltreatment when investigating brain structures.
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Full list of authors on original publication

Angela Carballedo, Thomas Frodl, Andrew Fagan, James Meaney

Experts in our system

1
Angela Carballedo
Trinity College Dublin
Total Publications: 23
 
2
Thomas Frodl
Trinity College Dublin
Total Publications: 58
 
3
Andrew John Fagan
Trinity College Dublin
Total Publications: 72
 
4
James Meaney
Trinity College Dublin
Total Publications: 28