Type

Journal Article

Authors

Joshua Balsters
Ian Robertson

Subjects

Psychiatry

Topics
fmri reaction time bold oscillations match to sample ica neuroscience ageing working memory

BOLD frequency power indexes working memory performance (2013)

Abstract Electrophysiology studies routinely investigate the relationship between neural oscillations and task performance. However, the sluggish nature of the BOLD response means that few researchers have investigated the spectral properties of the BOLD signal in a similar manner. For the first time we have applied group ICA to fMRI data collected during a stan- dard working memory task (delayed match-to-sample) and using a multivariate analysis, we investigate the relationship between working memory performance (accuracy and reaction time) and BOLD spectral power within functional networks. Our results indicate that BOLD spectral power within specific networks (visual, temporal-parietal, posterior default-mode network, salience network, basal ganglia) correlated with task accuracy. Multivariate analy- ses show that the relationship between task accuracy and BOLD spectral power is stronger than the relationship between BOLD spectral power and other variables (age, gender, head movement, and neuropsychological measures). A traditional General Linear Model (GLM) analysis found no significant group differences, or regions that covaried in signal intensity with task accuracy, suggesting that BOLD spectral power holds unique information that is lost in a standard GLM approach. We suggest that the combination of ICA and BOLD spectral power is a useful novel index of cognitive performance that may be more sensitive to brain-behavior relationships than traditional approaches
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Full list of authors on original publication

Joshua Balsters, Ian Robertson

Experts in our system

1
Joshua Balsters
Trinity College Dublin
Total Publications: 23
 
2
Ian H Robertson
Trinity College Dublin
Total Publications: 142