Type

Journal Article

Authors

Gary Donohoe
Hugh Garavan

Subjects

Psychiatry

Topics
anterior cingulate adolescents inhibitory control resting state treatment intrinsic functional connectivity functional connectivity neural networks psychosis psychotic symptoms functional magnetic resonance imaging

Resting-state connectivity deficits associated with impaired inhibitory control in non-treatment-seeking adolescents with psychotic symptoms (2014)

Abstract Objective— Psychotic symptoms are common in the population and index risk for a range of severe psychopathological outcomes. We wished to investigate functional connectivity in a community sample of adolescents who reported psychotic symptoms (the extended psychosis phenotype). Method— This study investigated intrinsic functional connectivity (iFC) during resting-state functional magnetic resonance imaging (fMRI; rs-fMRI). Following screening in schools, 11 non- treatment seeking, youth with psychotic symptoms (aged 11–13) and 14 community controls participated in the study. Seed regions of interest comprised brain regions previously shown to exhibit aberrant activation during inhibitory control in adolescents with psychotic symptoms. Results— Relative to controls, adolescents with psychotic symptoms exhibited reduced iFC between regions supporting inhibitory control. Specifically, they showed weaker iFC between the right inferior frontal gyrus (IFG) and the cingulate, IFG and the striatum, anterior cingulate and claustrum, and precuneus and supramarginal gyrus. Conversely, the psychotic symptoms group exhibited stronger iFC between the superior frontal gyrus and claustrum and IFG and lingual gyrus. Conclusion— The present findings are the first to reveal aberrant functional connectivity in resting-state networks in a community sample of adolescents with psychotic symptoms and suggest that disruption in integration between distributed neural networks (particularly between
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Full list of authors on original publication

Gary Donohoe, Hugh Garavan

Experts in our system

1
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
2
Hugh Garavan
Trinity College Dublin
Total Publications: 160