Journal Article


Colum Dunne
Miranda G Kiernan
John Fenton
Nuala H O'Connell
Linda Kearse
Barry Linnane



old irish male bronchoalveolar lavage colonisation detection eradication regimen pseudomonas aeruginosa lung function cystic fibrosis paranasal sinuses

A case of failed eradication of cystic fibrosis-related sinus colonisation by Pseudomonas aeruginosa (2015)

Abstract Background: Pseudomonas aeruginosa is a pathogen associated with cystic fibrosis that has potential to decrease lung function and cause respiratory failure. Paranasal sinuses are increasingly recognised as potential reservoirs for intermittent colonisation by P. aeruginosa. This case documents investigation and outcome of P. aeruginosa recurrence in a male paediatric patient over an eight year period. Case presentation: A 12 year old Irish male paediatric cystic fibrosis patient experienced intermittent culturing of P. aeruginosa from the oropharyngeal region, indicating chronic infection of the sinuses despite absence of symptoms, retaining good lung function, and normal bronchoscopy and bronchoalveloar lavage. However, P. aeruginosa was isolated from a sinus wash-out and was identified as a unique strain of P. aeruginosa that was also cultured from cough swabs. Despite treatment, successful eradication from the paranasal sinuses was not achieved. Conclusions: Few reports have addressed the paranasal sinuses as a reservoir for lung infection in cystic fibrosis patients despite increased recognition of the need to investigate this niche. In this case, attempts at eradication of P. aeruginosa present in paranasal sinuses including oral and nebulised antimicrobials proved unsuccessful. However, detection of P. aeruginosa in the paranasal sinuses instigated antimicrobial treatment which may have contributed to prevention of migration to the lower airways. Our outcome provides additional insight and may indicate utility of nasal lavage or nasal endoscopy in paediatric cystic fibrosis patients’ annual review clinic visits.
Collections Ireland -> University of Limerick -> Graduate Entry Medical School
Ireland -> University of Limerick -> Faculty of Education & Health Sciences
Ireland -> University of Limerick -> Departments Education & Health Sciences
Ireland -> University of Limerick -> Centres Education & Health Sciences
Ireland -> University of Limerick -> 4i - Centre for Interventions in Infection, Inflammation & Immunity

Full list of authors on original publication

Colum Dunne, Miranda G Kiernan, John Fenton, Nuala H O'Connell, Linda Kearse, Barry Linnane

Experts in our system

Colum P Dunne
University of Limerick
Total Publications: 178
Miranda G Kiernan
University of Limerick
Total Publications: 18
J E Fenton
University of Limerick
Total Publications: 14
Nuala H O'Connell
University of Limerick
Total Publications: 51
Barry Linnane
University of Limerick
Total Publications: 27