Type

Journal Article

Authors

Niall P Pender
Michael Marnane
Conor Fearon
Joshua H Balsters
Ian H Robertson
Tim Lynch
Paul Michael Dockree
Simona Salomone

Subjects

Psychiatry

Topics
progressive treatment voxel based morphometry cognitive function white matter attention ras reticular activating system memory autoimmune coma executive functions higher order functions

The effects of immunologic brainstem encephalopathy on cognitive function following awakening from a progressive autoimmune coma. (2013)

Abstract We describe a unique patient who experienced a progressive autoimmune coma from age 14 to 17. The patient awoke after treatment with immunosuppressant medication. Although alertness, verbalization, and mobilization markedly improved, the patient reported persistent cognitive difficulties. Neuropsychological assessment from age 21 showed impairments in selective attention, distractibility, and memory. Conversely, higher-order executive functions were preserved. Electrophysiological analysis also identified abnormal neural signatures of selective attention. Eighteen months after the neuropsychological assessment, voxel-based morphometry revealed reduced white matter in the medulla compared to controls. The findings are discussed in terms of the impact of brainstem encephalopathy on cognitive mechanisms.
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Full list of authors on original publication

Niall P Pender, Michael Marnane, Conor Fearon, Joshua H Balsters, Ian H Robertson, Tim Lynch, Paul Michael Dockree, Simona Salomone

Experts in our system

1
Niall P Pender
Trinity College Dublin
Total Publications: 19
 
2
Michael Marnane
Royal College of Surgeons in Ireland
Total Publications: 4
 
3
Conor Fearon
Dublin Institute of Technology
Total Publications: 5
 
4
Joshua Balsters
Trinity College Dublin
Total Publications: 23
 
5
Ian H Robertson
Trinity College Dublin
Total Publications: 142
 
6
Tim Lynch
University College Dublin
Total Publications: 12
 
7
Paul M Dockree
Trinity College Dublin
Total Publications: 32
 
8
Simona Salomone
Trinity College Dublin
Total Publications: 5