Type

Journal Article

Authors

M Murphy
M McLoughlin
R Donnelly
N Murphy
E Barrett
P.M Jakeman
P Carroll

Subjects

Physiotherapy & Sport

Topics
post menopausal women healthy young males measurement critical bone turnover national bone resorption biological markers

Biological day-to-day variability and critical differences in the serial measurement of two markers of bone turnover in the sera of healthy young males. National (2002)

Abstract The study outlined here is part of an overall project, which aims to identify the optimum marker of bone resorption for both healthy young males and post-menopausal, non-osteoporotic women, and is as yet ongoing1. The purpose of this investigation was to quantify the biological day-to-day variability in serum levels of N-Mid Osteocalcin (OC; ng/ml) and CrossLaps (ng/ml) in healthy males (n=14). From this biological variation (CVi: individual biological variability), the critical difference (CD) or least significant change was calculated as previously described2. This value represents the minimal difference between two measurements of a biochemical marker that indicates a medically significant alteration of homeostasis (and is not due to normal biological and/or analytical variability alone). Given the CD of these markers the viability of using them in the assessment and/or monitoring of bone metabolism will be considered.
Collections Ireland -> University of Limerick -> Faculty of Education & Health Sciences
Ireland -> University of Limerick -> Departments Education & Health Sciences
Ireland -> University of Limerick -> Physical Education and Sports Science

Full list of authors on original publication

M Murphy, M McLoughlin, R Donnelly, N Murphy, E Barrett, P.M Jakeman, P Carroll

Experts in our system

1
Marie H Murphy
University of Limerick
Total Publications: 25
 
2
Niamh Murphy
University of Limerick
Total Publications: 36
 
3
Eva Barrett
University of Limerick
Total Publications: 16
 
4
Philip M Jakeman
University of Limerick
Total Publications: 63