Journal Article


James D McKay
Ruth F Jarrett
Henrik Hjalgrim
Anke van den Berg
Arjan Diepstra
Paul Brennan
Mads Melbye
Mark Lathrop
Silvia de Sanjosé
Eve Roman
and 20 others


Medicine & Nursing

hodgkin lymphoma cell european epstein barr virus etiology cancer population independent study

A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma. (2015)

Abstract A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein-Barr virus (EBV) status, particularly within the MHC region. We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls. We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and cHL. Although strongly associated with EBV-positive cHL [OR, 2.33; 95% confidence interval (CI), 1.83-2.97; P = 7 × 10(-12)], there was little evidence for association between rs6457715 and the EBV-negative subgroup of cHL (OR, 1.06; 95% CI, 0.92-1.21), indicating that this association was specific to the EBV-positive subgroup (Phet < P = 10(-8)). Furthermore, the association was limited to EBV-positive cHL subgroups within mixed cell (MCHL) and nodular sclerosis subtypes (NSHL), suggesting that the association is independent of histologic subtype of cHL. rs6457715, located near the HLA-DPB1 gene, is associated with EBV-positive cHL and suggests this region as a novel susceptibility locus for cHL. This expands the number of genetic variants that are associated with cHL and provides additional evidence for a critical and specific role of EBV in the etiology of this disease. Cancer Epidemiol Biomarkers Prev; 24(12); 1838-43. ©2015 AACR.
Collections Ireland -> Dublin City University -> PubMed

Full list of authors on original publication

James D McKay, Ruth F Jarrett, Henrik Hjalgrim, Anke van den Berg, Arjan Diepstra, Paul Brennan, Mads Melbye, Mark Lathrop, Silvia de Sanjosé, Eve Roman and 20 others

Experts in our system

Paul Brennan
Dublin City University
Total Publications: 41