Journal Article


Richard J O'Kennedy
Aoife S Crawley


Medicine & Nursing

therapy management detection early diagnosis pancreatic cancer effective this review biomarker

The need for effective pancreatic cancer detection and management: a biomarker-based strategy. (2015)

Abstract Pancreatic cancer (Pa) is generally a very aggressive disease, with few effective approaches available for early diagnosis or therapy. These factors, combined with the aggressiveness and chemoresistance of Pa, results in a bleak outcome post-diagnosis. Cancer-related biomarkers have established capabilities for diagnosis, prognosis and screening and can be exploited to aid in earlier less-invasive diagnosis and optimization of targeted therapies. Pa has only one US FDA-approved biomarker, CA19-9, which has significant limitations. Hence, it is vital that novel biomarkers are identified and validated to diagnose, treat, control and monitor Pa. This review focuses on existing and potential Pa-associated markers and discusses how they may be applied in cohort for improved management of Pa.
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Full list of authors on original publication

Richard J O'Kennedy, Aoife S Crawley

Experts in our system

R O'Kennedy
Dublin City University
Total Publications: 197