Type

Journal Article

Authors

Dara M Cannon
Colm McDonald
Brian Hallahan
Gary Donohoe
Mohamed Ahmed
Fintan Byrne
John McFarland
Shane McInerney
Elisabeth Scherz
Sophia Arndt
and 3 others

Subjects

Psychiatry

Topics
clinical study social cognition consensus longitudinal study first episode psychosis verbal learning follow up cognitive

Cognitive course in first-episode psychosis and clinical correlates: A 4year longitudinal study using the MATRICS Consensus Cognitive Battery. (2015)

Abstract While cognitive impairments are prevalent in first-episode psychosis, the course of these deficits is not fully understood. Most deficits appear to remain stable, however there is uncertainty regarding the trajectory of specific cognitive domains after illness onset. This study investigates the longitudinal course of cognitive deficits four years after a first-episode of psychosis and the relationship of performance with clinical course and response to treatment. Twenty three individuals with psychotic illness, matched with 21 healthy volunteers, were assessed using the MATRICS Consensus Cognitive Battery at illness onset and 4years later. We also investigated the relationship between cognitive deficits and quality of life and clinical indices. Verbal learning and two measures of processing speed had marked poorer trajectory over four years compared to the remaining cognitive domains. Processing speed performance was found to contribute to the cognitive deficits in psychosis. Poorer clinical outcome was associated with greater deficits at illness onset in reasoning and problem solving and social cognition. Cognitive deficits did not predict quality of life at follow-up, nor did diagnosis subtype differentiate cognitive performance. In conclusion, an initial psychotic episode may be associated with an additional cost on verbal learning and two measures of processing speed over a time spanning at least four years. Moreover, processing speed, which has been manipulated through intervention in previous studies, may represent a viable therapeutic target. Finally, cognition at illness onset may have a predictive capability of illness course.
Collections Ireland -> National University of Ireland Galway -> PubMed

Full list of authors on original publication

Dara M Cannon, Colm McDonald, Brian Hallahan, Gary Donohoe, Mohamed Ahmed, Fintan Byrne, John McFarland, Shane McInerney, Elisabeth Scherz, Sophia Arndt and 3 others

Experts in our system

1
Dara M. Cannon
National University of Ireland Galway
Total Publications: 29
 
2
Colm McDonald
National University of Ireland Galway
Total Publications: 43
 
3
Brian Hallahan
National University of Ireland Galway
Total Publications: 20
 
4
Gary Donohoe
Trinity College Dublin
Total Publications: 130
 
5
Mohamed Ahmed
National University of Ireland Galway
Total Publications: 5
 
6
John McFarland
National University of Ireland Galway
Total Publications: 6
 
7
Shane McInerney
National University of Ireland Galway
Total Publications: 7