Type

Journal Article

Authors

David C Henshall
Rana Raoof
Brett A Becker
Catherine Mooney

Subjects

Biochemistry

Topics
epilepsy biomarkers of epilepsy human tissue gene expression brain rna microrna micrornas blood gene expression regulation cell death database

EpimiRBase: a comprehensive database of microRNA-epilepsy associations. (2016)

Abstract MicroRNAs are short non-coding RNA which function to fine-tune protein levels in all cells. This is achieved mainly by sequence-specific binding to 3' untranslated regions of target mRNA. The result is post-transcriptional interference in gene expression which reduces protein levels either by promoting destabilisation of mRNA or translational repression. Research published since 2010 shows that microRNAs are important regulators of gene expression in epilepsy. A series of microRNA profiling studies in rodent and human tissue has revealed epilepsy is associated with wide ranging changes to microRNA levels in the brain. These are thought to influence processes including cell death, inflammation and re-wiring of neuronal networks. MicroRNAs have also been identified in the blood after injury to the brain and therefore may serve as biomarkers of epilepsy. EpimiRBase is a manually curated database for researchers interested in the role of microRNAs in epilepsy. The fully-searchable database includes information on up- and down-regulated microRNAs in the brain and blood, as well as functional studies, and covers both rodent models and human epilepsy. EpimiRBase is available at http://www.epimirbase.eu CONTACT: catherinemooney@rcsi.ie.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed
Ireland -> University College Dublin -> College of Science
Ireland -> University College Dublin -> Computer Science Research Collection
Ireland -> University College Dublin -> School of Computer Science

Full list of authors on original publication

David C Henshall, Rana Raoof, Brett A Becker, Catherine Mooney

Experts in our system

1
David C Henshall
Royal College of Surgeons in Ireland
Total Publications: 127
 
2
Rana Raoof
University College Dublin
Total Publications: 7
 
3
Catherine Mooney
University College Dublin
Total Publications: 63