Type

Journal Article

Authors

Noel G McElvaney
Tomás P Carroll
Emer P Reeves
Killian Hurley

Subjects

Medicine & Nursing

Topics
chronic obstructive pulmonary disease copd alpha 1 antitrypsin deficiency lung disease tumor necrosis factor alpha treatment inflammation model driven neutrophil elastase

Tumor necrosis factor-α driven inflammation in alpha-1 antitrypsin deficiency: a new model of pathogenesis and treatment. (2015)

Abstract Alpha-1 antitrypsin (AAT) deficiency (AATD) has traditionally been thought of as a genetic disorder characterized by lung destruction and early emphysema in a low AAT, and high neutrophil elastase (NE) environment in the lungs of affected individuals. Recently, a growing body of evidence has emerged to support the hypothesis that tumor necrosis factor alpha (TNF-α) is essential in the pathogenesis of both genetic AATD and non-genetic chronic obstructive pulmonary disease (COPD). Reports have highlighted the importance of TNF-α driven immune cell dysfunction in the development of lung disease in AATD. The authors discuss the role of AAT as a key modulator of TNF-α signaling firstly in the setting of AATD and secondly in other conditions where AAT augmentation therapy has potential utility as a novel therapy.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Noel G McElvaney, Tomás P Carroll, Emer P Reeves, Killian Hurley

Experts in our system

1
Noel G McElvaney
Royal College of Surgeons in Ireland
Total Publications: 194
 
2
Tomás P Carroll
Royal College of Surgeons in Ireland
Total Publications: 26
 
3
Emer P Reeves
Royal College of Surgeons in Ireland
Total Publications: 63