Journal Article


Kenneth J O'Byrne
William M Gallagher
Finbarr O'Connell
Elaine Kay
Dearbhaile M O'Donnell
David Delaney
Linda Coate
Kathy Gately
Elton Rexhepaj
Dermot S O'Callaghan


Medicine & Nursing

cancer cell cell count tumour image analysis algorithm analysis multivariate analysis lung cancer t cell

Tumour islet Foxp3+ T-cell infiltration predicts poor outcome in nonsmall cell lung cancer. (2015)

Abstract The impact of host immunity on outcome in nonsmall cell lung cancer (NSCLC) is controversial. We examined the relationship between lymphoid infiltration patterns in NSCLC and prognosis.Tumour- and stroma-infiltrating CD3(+), CD8(+) and forkhead box P3 (Foxp3)(+) T-lymphocytes were identified using immunohistochemistry and a novel image analysis algorithm to assess total, cytotoxic and regulatory T-lymphocyte counts, respectively, in 196 NSCLC cases. The median cell count was selected as a cut-point to define patient subgroups and the ratio of the corresponding tumour islet:stroma (TI/S) counts was determined.There was a positive association between overall survival and increased CD8(+) TI/S ratio (hazard ratio (HR) for death 0.44, p<0.001) but an inverse relationship between Foxp3(+) TI/S ratio and overall survival (HR 4.86, p<0.001). Patients with high CD8(+) islet (HR 0.48, p<0.001) and Foxp3(+) stromal (HR 0.23, p<0.001) counts had better survival, whereas high CD3(+) and CD8(+) stromal counts and high Foxp3(+) islet infiltration conferred a worse survival (HR 1.55, 2.19 and 3.14, respectively). By multivariate analysis, a high CD8(+) TI/S ratio conferred an improved survival (HR 0.48, p=0.002) but a high Foxp3(+) TI/S ratio was associated with worse survival (HR 3.91, p<0.001).Microlocalisation of infiltrating T-lymphocytes is a powerful predictor of outcome in resected NSCLC.
Collections Ireland -> Royal College of Surgeons in Ireland -> PubMed

Full list of authors on original publication

Kenneth J O'Byrne, William M Gallagher, Finbarr O'Connell, Elaine Kay, Dearbhaile M O'Donnell, David Delaney, Linda Coate, Kathy Gately, Elton Rexhepaj, Dermot S O'Callaghan

Experts in our system

Kenneth J O'Byrne
Trinity College Dublin
Total Publications: 37
William M Gallagher
University College Dublin
Total Publications: 148
Elaine W Kay
Royal College of Surgeons in Ireland
Total Publications: 157
Dearbhaile O'Donnell
Trinity College Dublin
Kathy Gately
Trinity College Dublin
Total Publications: 22