Type

Journal Article

Authors

R P Ross
Colin Hill
Paul D Cotter
Des Field

Subjects

Chemistry

Topics
success physico chemical properties post translational modification therapeutic bacterial resistance mutagenesis bioengineering nisin bacteriocin systems engineering science foundation ireland sfi antibiotic antimicrobial peptide lantibiotics antimicrobial activity antimicrobial peptides

Bioengineering Lantibiotics for Therapeutic Success. (2015)

Abstract Several examples of highly modified antimicrobial peptides have been described. While many such peptides are non-ribosomally synthesized, ribosomally synthesized equivalents are being discovered with increased frequency. Of the latter group, the lantibiotics continue to attract most attention. In the present review, we discuss the implementation of in vivo and in vitro engineering systems to alter, and even enhance, the antimicrobial activity, antibacterial spectrum and physico-chemical properties, including heat stability, solubility, diffusion and protease resistance, of these compounds. Additionally, we discuss the potential applications of these lantibiotics for use as therapeutics.
Collections Ireland -> Teagasc -> PubMed
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Ireland -> Teagasc -> Food Programme

Full list of authors on original publication

R P Ross, Colin Hill, Paul D Cotter, Des Field

Experts in our system

1
R Paul Ross
Teagasc
Total Publications: 441
 
2
Colin Hill
University College Cork
Total Publications: 351
 
3
Paul D. Cotter
Teagasc
Total Publications: 253
 
4
Des Field
Teagasc
Total Publications: 30